How to get there? Is a little bit harder to get to but doable. Obviously if you are not a cheap backpacker you can hire a car or a private transfer but what is the fun in that, am I right? Here are the instructions for the bus.
There are daily departures [7:30 am, 12:30 pm, and 1:45 pm] from Cancun to Chiquila from the main bus terminal in Cancun City. From Chiquila you will get the ferry.
If you are going straight from the Cancun airport there is an Airport ADO Bus that runs approx every hour from 7:00am to 10:00pm. It leaves from the airport Terminals 2 and 3 and goes to the downtown central bus station in Cancun City on Tulum Ave.
There if you arrive early enough you can catch the 7:30am MAYAB line bus to Chiquila. The next bus is at 12:30pm MAYAB line to Chiquila, and the last bus is 1:45pm NORESTE bus line.
Many flights arrive in Cancun too late to make these connections so you might have to spend one night downtown at a hotel close to the Bus Station.
Going back to Cancun from Holbox there is a 5:30am NORESTE bus from Chiquila, a 7:30am MAYAB Bus from Chiquila and finally a 1:30pm MAYAB bus from Chiquila.
You can also come from a place called Merida I went there from Holbox, here are the instructions for that. The only bus we know that travels to Chiquila from Merida is a late nighter departing from Merida main bus terminal at 11 pm.
Directions borrowed from: https://travelyucatan.com/getting-to-isla-holbox/
Where to stay? I stayed in a hostel called Tribu a very popular option, it was recommended to me by many. It has a kitchen, a bar, free yoga and nightly activities. Again you can find cheaper options online or if you walk around upon arrival and you can also camp on this island.
Where to eat? If you stay at Tribu they will give you a map and point out local markets and some restaurants. Otherwise most places are on the main road that leads from the ferry doc. We had amazing Pizza at the Pizza place and amazing ceviche and fish tacos at the little markets.
Best coffee (Australia standards) was at Tierra Mia.
Party? There are a few bars on the island to party at or Tribu.
Extra info.. Go see the flamingos and the HOLBOX hammocks in the water.
Next… This is a mini Cancun, Playa Del Carmen, lots of American tourists and huge party. Personally I only went because I was going to the music festival BPM.